Syt1^tm2Sud
Targeted Allele Detail

Summary

• Symbol: Syt1^tm2Sud
• Name: synaptotagmin I; targeted mutation 2, Thomas C Sudhof
• MGI ID: MGI:2180146
• Gene: Syt1 Location: Chr10:108333511-108846843 bp, - strand Genetic Position: Chr10, 56.52 cM
• Alliance: Syt1^tm2Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76452
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into intron 1 via homologous recombination and results in a normal protein product. Western blot of brain homogenates from homozygous mutant animals verified the presence of protein expression and enzyme assays demonstrated that the phospholipid- and syntaxin-binding ability of the protein remained intact. (J:76452)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syt1 Mutation: 41 strains or lines available

References

• Original: J:76452 Fernandez-Chacon R, et al., Synaptotagmin I functions as a calcium regulator of release probability. Nature. 2001 Mar 1;410(6824):41-9
• All: 2 reference(s)