Stx4a^tm1Jpes
Targeted Allele Detail

Summary

• Symbol: Stx4a^tm1Jpes
• Name: syntaxin 4A (placental); targeted mutation 1, Jeffrey E Pessin
• MGI ID: MGI:2180164
• Synonyms: Stx4a^tm1Jepn, syn4-, Syn4a^-
• Gene: Stx4a Location: Chr7:127439832-127450160 bp, + strand Genetic Position: Chr7, 69.77 cM, cytoband F4
• Alliance: Stx4a^tm1Jpes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69598
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 3.3 kb of the gene encompassing exons 1-5, and including the translation initiation site, was replaced with a neo resistance cassette via homologous recombination. Reduced protein expression was demonstrated by western blotting in heterozygous mice. (J:69598)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stx4a Mutation: 22 strains or lines available

References

• Original: J:69598 Yang C, et al., Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. J Clin Invest. 2001 May;107(10):1311-8
• All: 4 reference(s)