Ap1g1^tm1Schu
Targeted Allele Detail

Summary

• Symbol: Ap1g1^tm1Schu
• Name: adaptor protein complex AP-1, gamma 1 subunit; targeted mutation 1, Peter Schu
• MGI ID: MGI:2180169
• Synonyms: gamma-Adaptin ^-
• Gene: Ap1g1 Location: Chr8:110505215-110590842 bp, + strand Genetic Position: Chr8, 57.26 cM
• Alliance: Ap1g1^tm1Schu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53252
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette disrupted the exon that encodes amino acid residues 68 through 108. Northern and Western analyses of heterozygous animals showed roughly 70% and 50% reductions in expression, respectively. (J:53252)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ap1g1 Mutation: 47 strains or lines available

References

• Original: J:53252 Zizioli D, et al., Early embryonic death of mice deficient in gamma-adaptin. J Biol Chem. 1999 Feb 26;274(9):5385-90
• All: 1 reference(s)