Ap1m1^tm1Schu
Targeted Allele Detail

Summary

• Symbol: Ap1m1^tm1Schu
• Name: adaptor-related protein complex AP-1, mu subunit 1; targeted mutation 1, Peter Schu
• MGI ID: MGI:2180171
• Synonyms: delta-mu-1
• Gene: Ap1m1 Location: Chr8:72993862-73011229 bp, + strand Genetic Position: Chr8, 34.92 cM
• Alliance: Ap1m1^tm1Schu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62184
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted to disrupt an exon of the mu-adaptin gene. Northern analysis of total RNA isolated from homozygous embryos revealed an absence of transcript. Western analysis of homozygous mutants showed a 30% reduction in gamma-adaptin and a 70% reduction in sigma1-adaptin relative to a control. (J:62184)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ap1m1 Mutation: 15 strains or lines available

References

• Original: J:62184 Meyer C, et al., mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J. 2000 May 15;19(10):2193-203
• All: 1 reference(s)