Snap25^tm1Mcw
Targeted Allele Detail

Summary

• Symbol: Snap25^tm1Mcw
• Name: synaptosomal-associated protein 25; targeted mutation 1, Michael C Wilson
• MGI ID: MGI:2180178
• Synonyms: Snap25-
• Gene: Snap25 Location: Chr2:136555373-136624348 bp, + strand Genetic Position: Chr2, 67.56 cM
• Alliance: Snap25^tm1Mcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5a/b and part of the downstream intron were replaced with a PGK-neo cassette by homologous recombination. Western blot of brain proteins and RT-PCR analysis of total brain RNA from homozygous mutant embryos verified the absence of gene expression. (J:73755)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snap25 Mutation: 26 strains or lines available

References

• Original: J:73755 Washbourne P, et al., Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis. Nat Neurosci. 2002 Jan;5(1):19-26
• All: 32 reference(s)