Cacna1b^tm1Ksw
Targeted Allele Detail

Summary

• Symbol: Cacna1b^tm1Ksw
• Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 1, Kohei Sawada
• MGI ID: MGI:2180187
• Synonyms: alpha-, alpha1B^-, Cav2.2-
• Gene: Cacna1b Location: Chr2:24493899-24653164 bp, - strand Genetic Position: Chr2, 16.58 cM, cytoband A2
• Alliance: Cacna1b^tm1Ksw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76458
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The exon encoding the central portion of the cytoplasmic repeat II-III linker was disrupted by insertion of a PGK-neo cassette via homologous recombination. RT-PCR analysis verified the presence of mutant transcripts in brain of homozygous mutant animals. (J:76458)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1b Mutation: 104 strains or lines available

References

• Original: J:76458 Ino M, et al., Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5323-8
• All: 24 reference(s)