Galt^tm1Sgl
Targeted Allele Detail

Summary

• Symbol: Galt^tm1Sgl
• Name: galactose-1-phosphate uridyl transferase; targeted mutation 1, Stanton Segal
• MGI ID: MGI:2180188
• Synonyms: G
• Gene: Galt Location: Chr4:41755228-41758695 bp, + strand Genetic Position: Chr4, 22.07 cM
• Alliance: Galt^tm1Sgl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37472
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A HPRT cassette was used to replace a 700 nucleotide region containing exons 6, which encodes the catalytic site, 7, and 8. Enzyme activity in the livers of homozygous mutant mice was undetectable. (J:37472)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Galt Mutation: 16 strains or lines available

References

• Original: J:37472 Leslie ND, et al., A mouse model of galactose-1-phosphate uridyl transferase deficiency. Biochem Mol Med. 1996 Oct;59(1):7-12
• All: 5 reference(s)