Cacna1a^tm1Fcr
Targeted Allele Detail

Summary

• Symbol: Cacna1a^tm1Fcr
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1, Frederick Cancer Research and Development Center
• MGI ID: MGI:2180190
• Synonyms: Cacna1a^Fcrtm1
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^tm1Fcr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76459
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 14-17 of this gene, which encode the pore-lining domain and 3 transmembrane domains of domain II, were replaced with a neo resistance cassette via homologous recombination. Western blot of cerebellar and forebrain extracts from homozygous mutant mice verified the absence of protein product. (J:76459)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 118 strains or lines available

References

• Original: J:76459 Fletcher CF, et al., Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity. FASEB J. 2001 May;15(7):1288-90
• All: 3 reference(s)