Foxl1^tm1Hfk
Targeted Allele Detail

Summary

• Symbol: Foxl1^tm1Hfk
• Name: forkhead box L1; targeted mutation 1, Hiroshi Fukamachi
• MGI ID: MGI:2180191
• Synonyms: Fkh6-, Foxl1-
• Gene: Foxl1 Location: Chr8:121854679-121857383 bp, + strand Genetic Position: Chr8, 70.34 cM
• Alliance: Foxl1^tm1Hfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76379
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a lacZ-polyA-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant mice was confirmed via RNase protection assay. (J:76379)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxl1 Mutation: 12 strains or lines available

References

• Original: J:76379 Fukamachi H, et al., Mesenchymal transcription factor Fkh6 is essential for the development and differentiation of parietal cells. Biochem Biophys Res Commun. 2001 Feb 2;280(4):1069-76
• All: 4 reference(s)