Tbx21^tm1Glm
Targeted Allele Detail

Summary

• Symbol: Tbx21^tm1Glm
• Name: T-box 21; targeted mutation 1, Laurie H Glimcher
• MGI ID: MGI:2180194
• Synonyms: T-bet^-, Tbx21-
• Gene: Tbx21 Location: Chr11:96988897-97006157 bp, - strand Genetic Position: Chr11, 60.95 cM, cytoband D
• Alliance: Tbx21^tm1Glm page

Phenotype of aortic arch atherosclerotic lesions in Tbx21^tm1Glm/Tbx21^tm1Glm Ldlr^tm1Her/Ldlr^tm1Her and Ldlr^tm1Her/Ldlr^tm1Her mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73833
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was used to replace a 2 kb region containing exon 1 and its flanking sequence. An absence of mRNA and protein were observed in T cells isolated from the lymph nodes of homozygous mutant mice by Northern blot and Western blot analysis, respectively. (J:73833, J:96620)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tbx21 Mutation: 39 strains or lines available

References

• Original: J:73833 Szabo SJ, et al., Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 2002 Jan 11;295(5553):338-42
• All: 296 reference(s)