Ccl5^tm1Hso
Targeted Allele Detail

Summary

• Symbol: Ccl5^tm1Hso
• Name: C-C motif chemokine ligand 5; targeted mutation 1, Hiroshi Sato
• MGI ID: MGI:2180195
• Synonyms: CCL5-KO, RANTES-
• Gene: Ccl5 Location: Chr11:83416604-83421344 bp, - strand Genetic Position: Chr11, 50.66 cM
• Alliance: Ccl5^tm1Hso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75842
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 333 bp region of the gene containing the promoter, transcription and translation initiation sites, and part of exon 1 was replaced with a PGK-hygro cassette via homologous recombination. Northern blot analysis confirmed the absence of gene expression in homozygous mutant mice. (J:75842)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccl5 Mutation: 11 strains or lines available

References

• Original: J:75842 Makino Y, et al., Impaired T cell function in RANTES-deficient mice. Clin Immunol. 2002 Mar;102(3):302-9
• All: 44 reference(s)