Tnfsf14^tm1Lpc
Targeted Allele Detail

Summary

• Symbol: Tnfsf14^tm1Lpc
• Name: tumor necrosis factor (ligand) superfamily, member 14; targeted mutation 1, Lieping Chen
• MGI ID: MGI:2180198
• Synonyms: LIGHT-, LIGHT^null
• Gene: Tnfsf14 Location: Chr17:57496492-57501177 bp, - strand Genetic Position: Chr17, 29.71 cM, cytoband D-E1
• Alliance: Tnfsf14^tm1Lpc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76414
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant mice was confirmed via RT-PCR analysis of spleen cell RNA. (J:76414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf14 Mutation: 27 strains or lines available

References

• Original: J:76414 Tamada K, et al., Cutting Edge: Selective Impairment of CD8(+) T Cell Function in Mice Lacking the TNF Superfamily Member LIGHT. J Immunol. 2002 May 15;168(10):4832-5
• All: 12 reference(s)