Ugcg^tm1Rlp
Targeted Allele Detail

Summary

• Symbol: Ugcg^tm1Rlp
• Name: UDP-glucose ceramide glucosyltransferase; targeted mutation 1, Richard L Proia
• MGI ID: MGI:2180226
• Synonyms: Ugcg^deltaEX7Neo, Ugcg^KO
• Gene: Ugcg Location: Chr4:59189452-59222833 bp, + strand Genetic Position: Chr4, 32.44 cM, cytoband B3
• Alliance: Ugcg^tm1Rlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76736
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7 was replaced with a neomycin resistance gene via homologous recombination. PCR genotype analysis verified the presence of homozygous mutant embryos. (J:76736)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ugcg Mutation: 87 strains or lines available

References

• Original: J:76736 Yamashita T, et al., A vital role for glycosphingolipid synthesis during development and differentiation. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9142-7
• All: 5 reference(s)