Ugcg^tm2Rlp
Targeted Allele Detail

Summary

• Symbol: Ugcg^tm2Rlp
• Name: UDP-glucose ceramide glucosyltransferase; targeted mutation 2, Richard L Proia
• MGI ID: MGI:2180227
• Synonyms: Ugcg^{deltaEX7Hygro}
• Gene: Ugcg Location: Chr4:59189452-59222833 bp, + strand Genetic Position: Chr4, 32.44 cM, cytoband B3
• Alliance: Ugcg^tm2Rlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76736
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In mutant embyronic stem cells carrying the targeted mutation Ugcg^tm1Rlp, exon 7 of the second allele was targeted using a hygromycin resistance replacement vector. Enzyme assays performed on extracts from doubly mutant embryonic stem cells verified the absence enzyme activity. (J:76736)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ugcg Mutation: 87 strains or lines available

References

• Original: J:76736 Yamashita T, et al., A vital role for glycosphingolipid synthesis during development and differentiation. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9142-7
• All: 1 reference(s)