Fer^tm2Pag
Targeted Allele Detail

Summary

• Symbol: Fer^tm2Pag
• Name: FER tyrosine kinase; targeted mutation 2, Peter A Greer
• MGI ID: MGI:2180300
• Gene: Fer Location: Chr17:64170057-64446491 bp, + strand Genetic Position: Chr17, 33.06 cM
• Alliance: Fer^tm2Pag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67350
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A neo resistance cassette was introduced downstream of exon 20 via homologous recombination. Western blot analysis demonstrated that the neo cassette did not alter gene expression or protein stability in homozygous mutant animals. (J:67350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fer Mutation: 36 strains or lines available

References

• Original: J:67350 Craig AW, et al., Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation. Mol Cell Biol. 2001 Jan;21(2):603-13
• All: 1 reference(s)