Defb1^tm1Hgu
Targeted Allele Detail

Summary

• Symbol: Defb1^tm1Hgu
• Name: defensin beta 1; targeted mutation 1, MRC Human Genetics Unit
• MGI ID: MGI:2180302
• Synonyms: Defb1-
• Gene: Defb1 Location: Chr8:22266615-22285201 bp, + strand Genetic Position: Chr8, 10.35 cM, cytoband A4
• Alliance: Defb1^tm1Hgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76528
• Parent Cell Line: E14TG2aIV (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin resistance gene via homologous recombination. Northern blot of kidney RNA from homozygous mutant animals failed to detect gene expression. (J:76528)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Defb1 Mutation: 8 strains or lines available

References

• Original: J:76528 Morrison G, et al., Characterization of the mouse Beta defensin 1, defb1, mutant mouse model. Infect Immun. 2002 Jun;70(6):3053-60
• All: 1 reference(s)