Defb1^tm1Jmw
Targeted Allele Detail

Summary

• Symbol: Defb1^tm1Jmw
• Name: defensin beta 1; targeted mutation 1, James M Wilson
• MGI ID: MGI:2180305
• Synonyms: mBD-1-
• Gene: Defb1 Location: Chr8:22266615-22285201 bp, + strand Genetic Position: Chr8, 10.35 cM, cytoband A4
• Alliance: Defb1^tm1Jmw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76529
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance gene via homologous recombination. Gene expression is absent in kidneys and trachea of homozygous mutant animals as determined by Northern blot analysis, RNase protection assay, and RT-PCR. (J:76529)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Defb1 Mutation: 8 strains or lines available

References

• Original: J:76529 Moser C, et al., beta-Defensin 1 contributes to pulmonary innate immunity in mice. Infect Immun. 2002 Jun;70(6):3068-72
• All: 3 reference(s)