Arhgdib^tm1Len
Targeted Allele Detail

Summary

• Symbol: Arhgdib^tm1Len
• Name: Rho, GDP dissociation inhibitor beta; targeted mutation 1, Michael Lenardo
• MGI ID: MGI:2180327
• Synonyms: Ly-GDI^-
• Gene: Arhgdib Location: Chr6:136900653-136918895 bp, - strand Genetic Position: Chr6, 66.72 cM, cytoband G1
• Alliance: Arhgdib^tm1Len page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42604
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced a 1.2-kb region containing exon 3. Neither RNA or protein expression was detected in thymocytes isolated from homozygous mutant animals by Northern and Western blot analysis, respectively. (J:42604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgdib Mutation: 16 strains or lines available

References

• Original: J:42604 Yin L, et al., Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases. Mol Immunol. 1997 Apr;34(6):481-91
• All: 1 reference(s)