Phox2a^tm1Jbr
Targeted Allele Detail

Summary

• Symbol: Phox2a^tm1Jbr
• Name: paired-like homeobox 2a; targeted mutation 1, Jean-Francois Brunet
• MGI ID: MGI:2180328
• Synonyms: Phox2a^-
• Gene: Phox2a Location: Chr7:101467520-101471933 bp, + strand Genetic Position: Chr7, 54.66 cM
• Alliance: Phox2a^tm1Jbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39084
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette was used to delete a portion of exon 2 and all of exon 3, eliminating the sequences encoding the homeodomain and all downstream sequence. The truncated message was believed to be unstable due to the absence of a signal in Northern blot analysis. (J:39084)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phox2a Mutation: 10 strains or lines available

References

• Original: J:39084 Morin X, et al., Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron. 1997 Mar;18(3):411-23
• All: 4 reference(s)