Gap43^tm1Kmr
Targeted Allele Detail

Summary

• Symbol: Gap43^tm1Kmr
• Name: growth associated protein 43; targeted mutation 1, Karina F Meiri
• MGI ID: MGI:2180341
• Synonyms: GAP43-
• Gene: Gap43 Location: Chr16:42068915-42161014 bp, - strand Genetic Position: Chr16, 28.37 cM
• Alliance: Gap43^tm1Kmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56646
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by insertion of a PGK-neo derived cassette via homologous recombination. Western blot analysis verified the absence of gene product in brain of homozygous mutant mice. (J:56646)

Expression

In Mice Carrying this Mutation:	21 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gap43 Mutation: 27 strains or lines available

References

• Original: J:56646 Maier DL, et al., Disrupted cortical map and absence of cortical barrels in growth-associated protein (GAP)-43 knockout mice. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9397-402
• All: 15 reference(s)