Phox2a^tm1.1Sgu
Targeted Allele Detail

Summary

• Symbol: Phox2a^tm1.1Sgu
• Name: paired-like homeobox 2a; targeted mutation 1.1, Sarah Guthrie
• MGI ID: MGI:2180355
• Synonyms: Phox2a^tau-LacZ
• Gene: Phox2a Location: Chr7:101467520-101471933 bp, + strand Genetic Position: Chr7, 54.66 cM
• Alliance: Phox2a^tm1.1Sgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63720
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A derivative of Phox2a^tm1Sgu. The floxed neo gene was removed by breeding with animals carrying a cre transgene. The resulting locus encoded a fusion between a bifunctional tau-beta-galactosidase protein and the N terminus of the protein. (J:63720)

Expression

In Mice Carrying this Mutation:	60 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phox2a Mutation: 10 strains or lines available

References

• Original: J:63720 Jacob J, et al., Role of the target in the pathfinding of facial visceral motor axons. Mol Cell Neurosci. 2000 Jul;16(1):14-26
• All: 4 reference(s)