Tnp2^tm1Mzh
Targeted Allele Detail

Summary

• Symbol: Tnp2^tm1Mzh
• Name: transition protein 2; targeted mutation 1, Ming Zhao
• MGI ID: MGI:2180358
• Synonyms: Tnp2-
• Gene: Tnp2 Location: Chr16:10605799-10606519 bp, - strand Genetic Position: Chr16, 5.83 cM, cytoband B1-B3
• Alliance: Tnp2^tm1Mzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72107
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene was replaced with a neo cassette flanked by loxP sites via homologous recombination. Northern and Western blot analysis verified the absence of gene expression in testes of homozygous mutant animals. (J:72107)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnp2 Mutation: 5 strains or lines available

References

• Original: J:72107 Zhao M, et al., Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice. Mol Cell Biol. 2001 Nov;21(21):7243-55
• All: 4 reference(s)