Itpr1^tm1Tno
Targeted Allele Detail

Summary

• Symbol: Itpr1^tm1Tno
• Name: inositol 1,4,5-trisphosphate receptor 1; targeted mutation 1, Tetsuo Noda
• MGI ID: MGI:2180360
• Synonyms: InsP3R1-, IP3R1-
• Gene: Itpr1 Location: Chr6:108190057-108528070 bp, + strand Genetic Position: Chr6, 49.74 cM
• Alliance: Itpr1^tm1Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30633
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the first coding exon of the gene which contains 5' untranslated sequence and the sequence for the first 31 amino acids. A lack of protein from the cerebellum of homozygous mutant animals was demonstrated by Western analysis. Additional binding studies and Ca²⁺ release assays were incorporated to demonstrate the loss of function for this allele. (J:30633)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itpr1 Mutation: 184 strains or lines available

References

• Original: J:30633 Matsumoto M, et al., Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature. 1996 Jan 11;379(6561):168-71
• All: 26 reference(s)