Bmal1^tm1Bra
Targeted Allele Detail

Summary

• Symbol: Bmal1^tm1Bra
• Name: basic helix-loop-helix ARNT like 1; targeted mutation 1, Christopher A Bradfield
• MGI ID: MGI:2180361
• Synonyms: bmal1-, Bmal1-KO, mMop3^-, Mop3^-
• Gene: Bmal1 Location: Chr7:112806672-112913333 bp, + strand Genetic Position: Chr7, 59.17 cM, cytoband F2-F3
• Alliance: Bmal1^tm1Bra page

Joint abnormalities with ectopic ossification in Bmal1^tm1Bra/Bmal1^tm1Bra mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66502
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 4 containing the helix-loop-helix coding domain and all of exon 5 were replaced by a neomycin selection cassette. A larger transcript, resulting from a cryptic splice site between exon 3 and the neomycin resistance gene, was detected by Northern blot analysis. The polypeptide truncates 15 residues after this splice site, prior to the functional domains encoded by exon 4 in the wild-type locus. (J:66502)

Expression

In Mice Carrying this Mutation:	10 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	37 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bmal1^tm1Bra

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmal1 Mutation: 139 strains or lines available

References

• Original: J:66502 Bunger MK, et al., Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 2000 Dec 22;103(7):1009-17
• All: 151 reference(s)