Cav2^tm1Mls
Targeted Allele Detail

Summary

• Symbol: Cav2^tm1Mls
• Name: caveolin 2; targeted mutation 1, Michael P Lisanti
• MGI ID: MGI:2180372
• Synonyms: Cav-2-
• Gene: Cav2 Location: Chr6:17281184-17289114 bp, + strand Genetic Position: Chr6, 7.72 cM, cytoband A2
• Alliance: Cav2^tm1Mls page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75490
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 and part of the promoter region were replaced with a neo resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Western blot analysis of heart, adipose, and lung tissue. (J:75490)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cav2 Mutation: 18 strains or lines available

References

• Original: J:75490 Razani B, et al., Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol. 2002 Apr;22(7):2329-44
• All: 11 reference(s)