About   Help   FAQ
Cav2tm1Mls
Targeted Allele Detail
Summary
Symbol: Cav2tm1Mls
Name: caveolin 2; targeted mutation 1, Michael P Lisanti
MGI ID: MGI:2180372
Synonyms: Cav-2-
Gene: Cav2  Location: Chr6:17281184-17289114 bp, + strand  Genetic Position: Chr6, 7.72 cM, cytoband A2
Alliance: Cav2tm1Mls page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75490
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 and part of the promoter region were replaced with a neo resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Western blot analysis of heart, adipose, and lung tissue. (J:75490)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cav2 Mutation:  18 strains or lines available
References
Original:  J:75490 Razani B, et al., Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol. 2002 Apr;22(7):2329-44
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory