Selplg^tm1Rpmc
Targeted Allele Detail

Summary

• Symbol: Selplg^tm1Rpmc
• Name: selectin, platelet (p-selectin) ligand; targeted mutation 1, Rodger P McEver
• MGI ID: MGI:2180375
• Synonyms: PSGL-1-, PSGL-1 KO, Selpl^-
• Gene: Selplg Location: Chr5:113956597-113970705 bp, - strand Genetic Position: Chr5, 55.59 cM
• Alliance: Selplg^tm1Rpmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75829
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the 5' portion of exon 2, which includes the translation initiation start site, via homologous recombination. Flow cytometry was used to confirm the absence of gene expression in leukocytes of homozygous mutant animals. (J:75829, J:95268)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Selplg Mutation: 51 strains or lines available

References

• Original: J:75829 Xia L, et al., P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest. 2002 Apr;109(7):939-50
• All: 25 reference(s)