Arnt2^tm1Mcs
Targeted Allele Detail

Summary

• Symbol: Arnt2^tm1Mcs
• Name: aryl hydrocarbon receptor nuclear translocator 2; targeted mutation 1, M Celeste Simon
• MGI ID: MGI:2180386
• Synonyms: Arnt2^-
• Gene: Arnt2 Location: Chr7:83895486-84059201 bp, - strand Genetic Position: Chr7, 48.35 cM
• Alliance: Arnt2^tm1Mcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69874
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced a portion of the exon encoding the helix-loop-helix domain downstream of the splice acceptor site and the first 91 nucleotides. Western blot analysis of total RNA isolated from cortical neurons showed an absence of protein expression in homozygous mutant embryos. (J:69874)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arnt2 Mutation: 38 strains or lines available

References

• Original: J:69874 Keith B, et al., Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6692-7
• All: 1 reference(s)