Nhlh2^tm1Irk
Targeted Allele Detail

Summary

• Symbol: Nhlh2^tm1Irk
• Name: nescient helix loop helix 2; targeted mutation 1, Ilan R Kirsch
• MGI ID: MGI:2180391
• Synonyms: Nhlh2^-
• Gene: Nhlh2 Location: Chr3:101917425-101922808 bp, + strand Genetic Position: Chr3, 44.3 cM
• Alliance: Nhlh2^tm1Irk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39356
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a PGK-neo cassette. Transcript was undetected by Northern blot analysis of total RNA isolated from homozygous mutant embryos. (J:39356)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nhlh2 Mutation: 13 strains or lines available

References

• Original: J:39356 Good DJ, et al., Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Nat Genet. 1997 Apr;15(4):397-401
• All: 8 reference(s)