Cd247^tm1Mal
Targeted Allele Detail

Summary

• Symbol: Cd247^tm1Mal
• Name: CD247 antigen; targeted mutation 1, Bernard Malissen
• MGI ID: MGI:2180466
• Synonyms: zeta-sd
• Gene: Cd247 Location: Chr1:165616250-165704846 bp, + strand Genetic Position: Chr1, 73.14 cM, cytoband G-H
• Alliance: Cd247^tm1Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15272
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. Absence of gene expression in thymocytes of homozygous mutant animals was verified by Western blot analysis. This mutation disrupts the two major isoforms of this locus. (J:15272)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd247 Mutation: 11 strains or lines available

References

• Original: J:15272 Malissen M, et al., T cell development in mice lacking the CD3-zeta/eta gene. EMBO J. 1993 Nov;12(11):4347-55
• All: 14 reference(s)