Bace1^tm1Vas
Targeted Allele Detail

Summary

• Symbol: Bace1^tm1Vas
• Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Robert Vassar
• MGI ID: MGI:2180468
• Synonyms: BACE1^-
• Gene: Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
• Alliance: Bace1^tm1Vas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67736
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a 2.0 kb region containing exon 1, which encodes amino acids 1 through 87. Expressed protein was undetectable in the brains of homozygous mice through immunoblotting analysis. (J:67736)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bace1 Mutation: 30 strains or lines available

References

• Original: J:67736 Luo Y, et al., Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci. 2001 Mar;4(3):231-2
• All: 13 reference(s)