Tfap2b^tm1Rbu
Targeted Allele Detail

Summary

• Symbol: Tfap2b^tm1Rbu
• Name: transcription factor AP-2 beta; targeted mutation 1, Reinhard Buettner
• MGI ID: MGI:2180473
• Synonyms: AP-2Beta^-, Tcfap2b^tm1Rbu
• Gene: Tfap2b Location: Chr1:19279138-19308800 bp, + strand Genetic Position: Chr1, 6.19 cM, cytoband A2-A4
• Alliance: Tfap2b^tm1Rbu page

Postaxial accessory digits in Tfap2b^tm1Rbu/Tfap2b^tm1Rbu mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42260
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a PGK-neo cassette disrupted exon 4, which encodes an essential DNA binding domain. Northern blot and Western blot analyses showed an absence of transcript and protein, respectively, in midbrain lysates obtained from homozygous mutant mice. (J:42260)

Disease models

Expression

In Mice Carrying this Mutation:	63 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2b Mutation: 29 strains or lines available

References

• Original: J:42260 Moser M, et al., Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev. 1997 Aug 1;11(15):1938-48
• All: 15 reference(s)