Dlx5^tm1Levi
Targeted Allele Detail

Summary

• Symbol: Dlx5^tm1Levi
• Name: distal-less homeobox 5; targeted mutation 1, Giovanni Levi
• MGI ID: MGI:2180474
• Synonyms: Dlx5-lacZ, Dlx5/LacZ
• Gene: Dlx5 Location: Chr6:6877801-6882068 bp, - strand Genetic Position: Chr6, 2.83 cM
• Alliance: Dlx5^tm1Levi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56557
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containg a promoterless lacZ gene and a floxed neomycin resistance gene under the control of a RSV promoter was used to delete a region spanning from within exon 1 to the 5' region of exon 3. RT-PCR analysis showed an absence of transcript in total RNA obtained from homozygous mutant embryos. This allele was used to generate a subsequent allele, Dlx5^tm1.1Levi, which lacks the neomycin resistance gene. (J:56557)

Expression

In Mice Carrying this Mutation:	122 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	36 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlx5 Mutation: 25 strains or lines available

References

• Original: J:56557 Acampora D, et al., Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. 1999 Sep;126(17):3795-809
• All: 9 reference(s)