Il5ra^tm1Ktk
Targeted Allele Detail

Summary

• Symbol: Il5ra^tm1Ktk
• Name: interleukin 5 receptor, alpha; targeted mutation 1, Kiyoshi Takatsu
• MGI ID: MGI:2180501
• Synonyms: IL-5Ralpha^-
• Gene: Il5ra Location: Chr6:106687336-106725998 bp, - strand Genetic Position: Chr6, 49.19 cM
• Alliance: Il5ra^tm1Ktk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33140
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A stop codon was introduced into exon 5 and a neo cassette was inserted into exon 6 via homologous recombination. The neo insertion disrupts 4 cysteine residues that are conserved within the cytokine receptor family. Absence of gene expression was verified by flow cytometry analysis of resting peritoneal cells from homozygous mutant animals. (J:33140)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il5ra Mutation: 38 strains or lines available

References

• Original: J:33140 Yoshida T, et al., Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity. 1996 May;4(5):483-94
• All: 13 reference(s)