exma
Transgenic Allele Detail

Summary

• Symbol: exma
• Name: exencephaly and severe microphthalmia/anophthalmia
• MGI ID: MGI:2180503
• Synonyms: OVE597
• Gene: exma Location: ChrX:81992476-93167308 bp Genetic Position: ChrX, cytoband C/D
• Alliance: exma page

abnormal skull morphology image

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic
• Mutation: Other
• Mutation details: This mutant line arose from a screen of random insertional mutations produced by the injection of a transgenes into one cell embryos. Physical mapping of the integration site on the X chromosome and data from Southern analysis suggest that the a large segment of DNA encompassing Arx and including part of Pola1 was duplicated as a result of the insertion. (J:76080)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any exma Mutation: 0 strains or lines available

References

• Original: J:76080 Cunningham D, et al., exma: an X-linked insertional mutation that disrupts forebrain and eye development. Mamm Genome. 2002 Apr;13(4):179-85
• All: 1 reference(s)