Cacnb3^tm1Hssh
Targeted Allele Detail

Summary

• Symbol: Cacnb3^tm1Hssh
• Name: calcium channel, voltage-dependent, beta 3 subunit; targeted mutation 1, Hee-Sup Shin
• MGI ID: MGI:2180537
• Synonyms: beta3^-, Cavbeta3^-
• Gene: Cacnb3 Location: Chr15:98528721-98542410 bp, + strand Genetic Position: Chr15, 54.64 cM
• Alliance: Cacnb3^tm1Hssh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50152
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection gene replaced the entire coding region downstream of exon 1. Northern analysis showed a lack of transcript in the brains of homozygous mutant mice. (J:50152)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacnb3 Mutation: 26 strains or lines available

References

• Original: J:50152 Namkung Y, et al., Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12010-5
• All: 6 reference(s)