Ctnna1^{Gt(pGT1.8geo)4Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Ctnna1^{Gt(pGT1.8geo)4Pgr}
• Name: catenin alpha 1; gene trap 4, Peter Gruss
• MGI ID: MGI:2180540
• Synonyms: alpha-E-catenin^GT1
• Gene: Ctnna1 Location: Chr18:35251955-35387829 bp, + strand Genetic Position: Chr18, 18.89 cM
• Alliance: Ctnna1^{Gt(pGT1.8geo)4Pgr} page

Mutation origin

• Mutant Cell Line: VII-45
• Germline Transmission: Earliest citation of germline transmission: J:38208
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pSABetageo Vector Type: gene trap
• Mutation details: A gene trap vector containing a 5' splice acceptor site and an in-frame Beta-geo cassette inserted into the gene after codon 632, resulting in the expression of a fusion protein of E-catenin and beta-galactosidase. Immunoblots of lysates from homozygous mutant mice showed an absence of full length alpha-catenin and reduced levels of E-cadherin and beta-catenin. (J:38208)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnna1 Mutation: 133 strains or lines available

References

• Original: J:38208 Torres M, et al., An alpha-E-catenin gene trap mutation defines its function in preimplantation development. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):901-6
• All: 2 reference(s)