Cask^{Tg(Bnlf1)1Wln}
Transgenic Allele Detail

Summary

• Symbol: Cask^{Tg(Bnlf1)1Wln}
• Name: calcium/calmodulin dependent serine protein kinase; transgene insertion 1, Joanna B Wilson
• MGI ID: MGI:2180543
• Synonyms: PyLMP1, PyLMP.5
• Gene: Cask Location: ChrX:13383319-13713020 bp, - strand Genetic Position: ChrX, 8.43 cM
• Alliance: Cask^{Tg(Bnlf1)1Wln} page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A transgene containing the BNLF-1 gene of the Epstein Barr Virus inserted into an intron of the Cask gene. The intron separates the exons encoding the calmodulin binding domain, a domain common to both isoforms of this gene. The open reading frame was unaffected by the introduction, allowing for the possibility of a hybrid protein. It is unknown whether the resulting phenotype results from a gain of function or loss of function mutation. (J:10591, J:50453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cask Mutation: 14 strains or lines available

References

• Original: J:18214 Wilson JB, et al., Transgenic mouse model of X-linked cleft palate. Cell Growth Differ. 1993 Feb;4(2):67-76
• All: 5 reference(s)