Psmc3^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Psmc3^tm1Aki
• Name: proteasome (prosome, macropain) 26S subunit, ATPase 3; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2180548
• Synonyms: Psmc^-
• Gene: Psmc3 Location: Chr2:90884361-90889783 bp, + strand Genetic Position: Chr2, 50.44 cM
• Alliance: Psmc3^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63395
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.3-kb region comprised of exon 7 and a portion of exon 8 and encoding a conserved ATPase domain was replaced with a neomycin selection cassette. The targeting event was confirmed by Southern blot analysis. (J:63395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmc3 Mutation: 25 strains or lines available

References

• Original: J:63395 Sakao Y, et al., Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting. Genomics. 2000 Jul 1;67(1):1-7
• All: 1 reference(s)