Psmc4^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Psmc4^tm1Aki
• Name: proteasome (prosome, macropain) 26S subunit, ATPase, 4; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2180553
• Synonyms: Psmc4^-
• Gene: Psmc4 Location: Chr7:27741127-27749517 bp, - strand Genetic Position: Chr7, 16.11 cM
• Alliance: Psmc4^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63395
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was used to replace 1.0-kb region containing part of exon 8, all of exons 9 and 10 as well as part of exon 11. This region encodes the conserved ATPase domain. Southern blot analysis confirmed the targeting event. (J:63395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmc4 Mutation: 18 strains or lines available

References

• Original: J:63395 Sakao Y, et al., Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting. Genomics. 2000 Jul 1;67(1):1-7
• All: 1 reference(s)