Tg(Ckmm-Cav3)1Ysu
Transgene Detail

Summary

• Symbol: Tg(Ckmm-Cav3)1Ysu
• Name: transgene insertion 1, Yoshihide Sunada
• MGI ID: MGI:2180562
• Synonyms: CAV-3^P104L, mCAV-3Tg, TgCAV3M1
• Transgene: Tg(Ckmm-Cav3)1Ysu Location: unknown
• Alliance: Tg(Ckmm-Cav3)1Ysu page

Transgene origin

• Strain of Origin: (C57BL/Slc x DBA/Slc)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckmm-Cav3)1Ysu expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cav3 (MGI:107570)

• Mutation details: Sequence encoding Cav3 modified to contain proline to leucine missense mutation at codon 104 was adjoined to a 6.5-kb fragment of the Ckmm promoter region. Expression of the transgene and endogenous Cav3 gene were confirmed by Northern blot and RT-PCR analyses, respectively. (J:67174)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:67174 Sunada Y, et al., Transgenic mice expressing mutant caveolin-3 show severe myopathy associated with increased nNOS activity. Hum Mol Genet. 2001 Feb 1;10(3):173-8
• All: 7 reference(s)