Cck^tm1Lcs
Targeted Allele Detail

Summary

• Symbol: Cck^tm1Lcs
• Name: cholecystokinin; targeted mutation 1, Linda C Samuelson
• MGI ID: MGI:2180568
• Synonyms: CCK KO, Cck^lacZ
• Gene: Cck Location: Chr9:121318890-121324728 bp, - strand Genetic Position: Chr9, 72.43 cM, cytoband F4
• Alliance: Cck^tm1Lcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76894
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing a lacZ-neo fusiong gene was inserted into exon 2 to delete 168 nucleotides encoding the amino-terminal signal sequence in exon 2. Radioimmunoassays of brain and duodenum tissue from homozygous mutant mice showed an absence of bioactive protein product. (J:76894)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cck Mutation: 26 strains or lines available

References

• Original: J:76894 Lacourse KA, et al., Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol. 1999 May;276(5 Pt 1):G1302-9
• All: 17 reference(s)