Cblb^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Cblb^tm1Pngr
• Name: Casitas B-lineage lymphoma b; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:2180570
• Synonyms: Clb-b-
• Gene: Cblb Location: Chr16:51851593-52028410 bp, + strand Genetic Position: Chr16, 32.88 cM
• Alliance: Cblb^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76896
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced the region encoding a portion of the tyrosine kinase-binding and RING finger domains, corresponding to amino acids 300 through 340 of the encoded protein. Western blot analysis showed an absence of protein expression in lymph nodes and splenocytes from homozygous mice. (J:76896)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Cblb Mutation: 58 strains or lines available

References

• Original: J:76896 Bachmaier K, et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000 Jan 13;403(6766):211-6
• All: 37 reference(s)