Cblb^tm1Hua
Targeted Allele Detail

Summary

• Symbol: Cblb^tm1Hua
• Name: Casitas B-lineage lymphoma b; targeted mutation 1, Hua Gu
• MGI ID: MGI:2180572
• Synonyms: Cbl-b^-, Cblb-, Cblb^del
• Gene: Cblb Location: Chr16:51851593-52028410 bp, + strand Genetic Position: Chr16, 32.88 cM
• Alliance: Cblb^tm1Hua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76897
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection gene was inserted into exon 3 immediately downstream of the translation start codon. RT-PCR showed an absence of transcript in homozygous mutant mice while Western analysis further confirmed the abrogation by revealing a lack of protein expression. (J:76897)

Tumor Data

List all tumor models in MMHCdb carrying Cblb^tm1Hua

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cblb Mutation: 58 strains or lines available

References

• Original: J:76897 Chiang YJ, et al., Cbl-b regulates the CD28 dependence of T-cell activation. Nature. 2000 Jan 13;403(6766):216-20
• All: 49 reference(s)