Cckbr^tm1Kpn
Targeted Allele Detail

Summary

• Symbol: Cckbr^tm1Kpn
• Name: cholecystokinin B receptor; targeted mutation 1, Alan S Kopin
• MGI ID: MGI:2180591
• Gene: Cckbr Location: Chr7:105075201-105085546 bp, + strand Genetic Position: Chr7, 55.86 cM
• Alliance: Cckbr^tm1Kpn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49320
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette deleted sequence encoding transmembrane domains V through VII, which are essential for structure. Radiolabeled binding experiments of cerbral plasma membranes isolated from homozygous mutant mice confirmed a lack of functional protein. (J:49320)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cckbr Mutation: 24 strains or lines available

References

• Original: J:49320 Langhans N, et al., Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-deficient mice. Gastroenterology. 1997 Jan;112(1):280-6
• All: 15 reference(s)