Ccna1^tm1Djw
Targeted Allele Detail

Summary

• Symbol: Ccna1^tm1Djw
• Name: cyclin A1; targeted mutation 1, Debra J Wolgemuth
• MGI ID: MGI:2180633
• Synonyms: Ccna1-
• Gene: Ccna1 Location: Chr3:54952890-54962922 bp, - strand Genetic Position: Chr3, 26.52 cM
• Alliance: Ccna1^tm1Djw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51290
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.4 kb fragment including exon 1 and a portion of exon 2 was replaced by a PGK-hprt cassette. Northern blot analyses using probes for the 5' and 3' termini showed an absence of transcript in the testis of homozygous mutant mice.Normal protein was undetected by immunohistochemical staining. (J:51290)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccna1 Mutation: 28 strains or lines available

References

• Original: J:51290 Liu D, et al., Cyclin A1 is required for meiosis in the male mouse. Nat Genet. 1998 Dec;20(4):377-80
• All: 10 reference(s)