Ccnd1^tm1Dsn
Targeted Allele Detail

Summary

• Symbol: Ccnd1^tm1Dsn
• Name: cyclin D1; targeted mutation 1, Clive Dickson
• MGI ID: MGI:2180640
• Synonyms: Ccnd1(-), cyclin D1^-, Cyl-1^-
• Gene: Ccnd1 Location: Chr7:144483668-144493568 bp, - strand Genetic Position: Chr7, 88.92 cM
• Alliance: Ccnd1^tm1Dsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29258
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a PGK-neo cassette deleted 200 nucleotides of exon 1 encoding a portion of the LXCXE motif. Northern blot analysis revealed an absence of transcript in homozygous mutant mice. Protein expression was not detected by Western blot analyses of extracts from homozygous mutant kidney, lung, and seminal vesicle tissue. (J:29258)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd1 Mutation: 22 strains or lines available

References

• Original: J:29258 Fantl V, et al., Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev. 1995 Oct 1;9(19):2364-72
• All: 15 reference(s)