Ccnd2^tm1Wbg
Targeted Allele Detail

Summary

• Symbol: Ccnd2^tm1Wbg
• Name: cyclin D2; targeted mutation 1, Robert A Weinberg
• MGI ID: MGI:2180642
• Synonyms: CD2^-, cyclin D2-, D2^-
• Gene: Ccnd2 Location: Chr6:127102125-127129156 bp, - strand Genetic Position: Chr6, 61.92 cM
• Alliance: Ccnd2^tm1Wbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37092
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette deleted exons 1 and 2. Protein was not detected in lysates from homozygous mutant embryos by Western blot analysis. (J:37092)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ccnd2^tm1Wbg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd2 Mutation: 25 strains or lines available

References

• Original: J:37092 Sicinski P, et al., Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature. 1996 Dec 5;384(6608):470-4
• All: 57 reference(s)