Cul1^tmTye
Targeted Allele Detail

Summary

• Symbol: Cul1^tmTye
• Name: cullin 1; targeted mutation 1, Michael Tyers
• MGI ID: MGI:2180659
• Synonyms: Cul1-
• Gene: Cul1 Location: Chr6:47430516-47503078 bp, + strand Genetic Position: Chr6, 22.9 cM, cytoband B3
• Alliance: Cul1^tmTye page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58150
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection gene replaced exon 2, which encodes the initiation codon and an essential binding site. Gene expression and Western blot analyses indicated that the targeted locus was null. (J:58150)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul1 Mutation: 58 strains or lines available

References

• Original: J:58150 Wang Y, et al., Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E. Curr Biol. 1999 Oct 21;9(20):1191-4
• All: 1 reference(s)