Summary |
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Mutation origin |
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Mutation description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Find Mice (IMSR) |
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Notes |
Homozygous mutant mice accumulate T cell blasts in the lymph nodes and spleens which also infiltrate liver, heart, lung, and pancreas. Serum immunoglobulin is elevated, and the mice die by 3 to 4 weeks old. T cells proliferate when stimulated via T cell receptors, but are liable to Fas induced apoptosis (J:29652).
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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