Rel^tm1Hcl
Targeted Allele Detail

Summary

• Symbol: Rel^tm1Hcl
• Name: reticuloendotheliosis oncogene; targeted mutation 1, Hsiou-Chi Liou
• MGI ID: MGI:2180672
• Synonyms: c-Rel-
• Gene: Rel Location: Chr11:23686847-23720969 bp, - strand Genetic Position: Chr11, 14.36 cM
• Alliance: Rel^tm1Hcl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53513
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 (which encodes amino acids 102-130) was replaced with a neomycin resistance gene via homologous recombination. Western blot assay of spleen lysates from homozygous mutant animals verified the absence of gene expression. (J:53513)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rel Mutation: 45 strains or lines available

References

• Original: J:53513 Liou HC, et al., c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol. 1999 Mar;11(3):361-71
• All: 51 reference(s)